Raf-1 (phospho Ser642) Antibody
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產(chǎn)品名稱: Raf-1 (phospho Ser642) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Raf-1 (phospho Ser642) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Raf-1 (phospho Ser642) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Raf-1 (phospho Ser642) Antibody
的詳細(xì)介紹
Raf-1 (phospho Ser642) AntibodyProduct Profile
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Product Name
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Raf-1 (phospho Ser642) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1 activation (Dhillon and Kolch, 2002; Chong et al., 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al., 2005) with two sites participating: Ser301 and Ser642.1) Chong H, Vikis HG, Guan KL (2003) Mechanisms of regulating the Raf kinase family. Cellular Signalling 15:463-469.
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Immunogen
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Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser642 of rat Raf-1.
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Raf-1 (phospho Ser642) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, and non human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity
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BovineChickenDogHumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Raf-1 (phospho Ser642) AntibodyTarget Information
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Gene Symbol
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Raf1
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Alternative Names
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Raf
Proto-oncogene c-RAF
cRaf
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Molecular Weight(MW)
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74
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Raf-1 (phospho Ser642) AntibodyDatabase Links
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Entrez Gene
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24703
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Protein Accession
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P11345
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Raf-1 (phospho Ser642) AntibodyApplication
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Application Notes
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The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, and non human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Raf-1 (phospho Ser642) AntibodyAdditional Information
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Form
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Liquid
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Storage Instructions
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Raf-1 antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
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Storage Buffer
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100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
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