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產(chǎn)品資料

NFKB Antibody

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產(chǎn)品名稱: NFKB Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

NFKB Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。NFKB Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


NFKB Antibody  的詳細(xì)介紹

NFKB AntibodyProduct Profile

Product Name NFKB Antibody
Antibody Type Primary Antibodies
Product description 
					

						This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.1) Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)
					

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Immunogen 
This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105).

NFKB AntibodyKey Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WB

For WB starting dilution is: 1:1000:
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

NFKB AntibodyTarget Information

Gene Symbol NFKB1
Alternative Names
Nuclear factor NF-kappa-B p105 subunit
DNA-binding factor KBF1
EBP-1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Nuclear factor NF-kappa-B p50 subunit
NFKB1
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Molecular Weight(MW) 105 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Chicken

NFKB AntibodyDatabase Links

Entrez Gene 4790
Protein Accession P19838

NFKB AntibodyApplication

  • Application

    Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NFKB antibody detected the NFKB protein (arrow).

Application Notes
For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

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