14 3 3 zeta (phospho Ser58) Antibody
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產(chǎn)品名稱: 14 3 3 zeta (phospho Ser58) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
14 3 3 zeta (phospho Ser58) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。14 3 3 zeta (phospho Ser58) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
14 3 3 zeta (phospho Ser58) Antibody
的詳細介紹
14 3 3 zeta (phospho Ser58) AntibodyProduct Profile
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Product Name
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14 3 3 zeta (phospho Ser58) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.1) Gu YM, et al. (2006) FEBS Lett ; 580 (1): 305-310Powell DW, et al. (2003) Mol Cell Biol; 23 (15): 5376-5387Mackintosh C. (2004) Biochem J; 381 (Pt 2): 329-342.
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Immunogen
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14-3-3 zeta (Phospho-Ser58) antibody was raised against a peptide sequence around phosphorylation site of serine 58 (R-S-S (p) -W-R) derived from Human 14-3-3 zeta.
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14 3 3 zeta (phospho Ser58) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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14 3 3 zeta (phospho Ser58) AntibodyTarget Information
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Gene Symbol
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YWHAZ
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Molecular Weight(MW)
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28 kDa
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Tissue Specificity
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This antibody detects endogenous level of 14-3-3 zeta only when phosphorylated at serine 58.
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14 3 3 zeta (phospho Ser58) AntibodyDatabase Links
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Entrez Gene
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7534
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Protein Accession
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NP_001129171.1
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14 3 3 zeta (phospho Ser58) AntibodyApplication
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Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with UV using 14-3-3 zeta (Phospho-Ser58).
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3 zeta (Phospho-Ser58). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using 14-3-3 zeta (Phospho-Ser58).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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