CREB (phospho Ser129) Antibody
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產(chǎn)品名稱: CREB (phospho Ser129) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CREB (phospho Ser129) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。CREB (phospho Ser129) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
CREB (phospho Ser129) Antibody
的詳細(xì)介紹
CREB (phospho Ser129) AntibodyProduct Profile
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Product Name
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CREB (phospho Ser129) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.1) Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol ; 26: 4934 - 4948. Lilah Rothem, et al. (2004) Mol. Pharmacol ; 66: 1536 - 1543. Darren R. Tyson, et, al. (2002) Endocrinology; 143: 674. Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol ; 23: 1364.
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Immunogen
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CREB (Phospho-Ser129) antibody was raised against a peptide sequence around phosphorylation site of serine 129 (I-L-S (p) -R-R) derived from Human CREB.
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CREB (phospho Ser129) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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CREB (phospho Ser129) AntibodyTarget Information
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Gene Symbol
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CREB1
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Alternative Names
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CREB
HSP90B
HSPC2
HSPCB
CREB-1
CREB1
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Molecular Weight(MW)
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43 kDa
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Tissue Specificity
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This antibody detects endogenous level of CREB only when phosphorylated at serine 129.
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CREB (phospho Ser129) AntibodyDatabase Links
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Entrez Gene
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1385
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Protein Accession
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NP_004370.1
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CREB (phospho Ser129) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Phospho-Ser129).
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Application
Western blot analysis of lysed extracts from 293 cells untreated (Lane 1) or treated with UV (lane 2) using CREB (Phospho-Ser129).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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