IRS 1 (phospho Ser639) Antibody
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產(chǎn)品名稱: IRS 1 (phospho Ser639) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IRS 1 (phospho Ser639) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。IRS 1 (phospho Ser639) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
IRS 1 (phospho Ser639) Antibody
的詳細介紹
IRS 1 (phospho Ser639) AntibodyProduct Profile
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Product Name
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IRS 1 (phospho Ser639) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit1) Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25 (4): 1569-1575Batty IH, et al. (2004) Biochem J; 379 (Pt 3): 641-651
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Immunogen
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IRS-1 (Phospho-Ser639) antibody was raised against a peptide sequence around phosphorylation site of serine 639 (P-K-S (p) -V-S) derived from Human IRS-1.
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IRS 1 (phospho Ser639) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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IRS 1 (phospho Ser639) AntibodyTarget Information
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Gene Symbol
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IRS1
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Alternative Names
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HIRS-1
NFKB3
IRS-1
IRS1
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Molecular Weight(MW)
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180 kDa
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Tissue Specificity
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This antibody detects endogenous level of IRS-1 only when phosphorylated at serine 639.
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IRS 1 (phospho Ser639) AntibodyDatabase Links
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Entrez Gene
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3667
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Protein Accession
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NP_005535.1
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IRS 1 (phospho Ser639) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS-1 (Phospho-Ser639).
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Application
Western blot analysis of lysed extracts from 293 cells untreated or treated with serum using IRS-1 (Phospho-Ser639).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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