IRS 1 (phospho Ser312) Antibody
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產(chǎn)品名稱: IRS 1 (phospho Ser312) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IRS 1 (phospho Ser312) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。IRS 1 (phospho Ser312) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
IRS 1 (phospho Ser312) Antibody
的詳細介紹
IRS 1 (phospho Ser312) AntibodyProduct Profile
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Product Name
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IRS 1 (phospho Ser312) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit1) Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5): 2355-2360Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645
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Immunogen
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IRS-1 (Phospho-Ser312) antibody was raised against a peptide sequence around phosphorylation site of serine 312 (A-T-S (p) -P-A) derived from Human IRS-1.
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IRS 1 (phospho Ser312) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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IRS 1 (phospho Ser312) AntibodyTarget Information
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Gene Symbol
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IRS1
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Alternative Names
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HIRS-1
OCT1
OTF1
HIRS-1
IRS1
Insulin receptor substrate 1
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Molecular Weight(MW)
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180 kDa
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Tissue Specificity
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This antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.
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IRS 1 (phospho Ser312) AntibodyDatabase Links
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Entrez Gene
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3667
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Protein Accession
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NP_005535.1
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IRS 1 (phospho Ser312) AntibodyApplication
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Application
Western blot analysis of extract from 293 cells untreated or treated with insulin using IRS-1 (Phospho-Ser312).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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