P38 MAPK (phospho Tyr182) Antibody
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產(chǎn)品名稱: P38 MAPK (phospho Tyr182) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
P38 MAPK (phospho Tyr182) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。P38 MAPK (phospho Tyr182) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
P38 MAPK (phospho Tyr182) Antibody
的詳細(xì)介紹
P38 MAPK (phospho Tyr182) AntibodyProduct Profile
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Product Name
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P38 MAPK (phospho Tyr182) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.1) Ming Zheng, et al. (2005) The FASEB Journal. 19: 109-111Bernt van den et al. (2001) Blink Immunology, 166: 582-587Arshad Rahman, et al. (2004) Am J Physiol Lung Cell Mol Physiol 287: L1017-L1024Osamu Yoshino, et al. (2003) Endocrinology & Metabolism Vol. 88: 2236-2241
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Immunogen
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P38 MAPK (Phospho-Tyr182) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 182 (T-G-Y (p) -V-A) derived from Human P38 MAPK.
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P38 MAPK (phospho Tyr182) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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P38 MAPK (phospho Tyr182) AntibodyTarget Information
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Gene Symbol
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MAPK14
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Alternative Names
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RK
p38
CSBP
EXIP
Mxi2
CSBP1
CSBP2
CSPB1
PRKM14
PRKM15
SAPK2A
p38ALPHA
FLK1
VEGFR2
MAPK2
MAPKAPK-2
MAPKAPK2
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Molecular Weight(MW)
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43 kDa
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Tissue Specificity
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This antibody detects endogenous level of P38MAPK only when phosphorylated at tyrosine 182.
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P38 MAPK (phospho Tyr182) AntibodyDatabase Links
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Entrez Gene
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1432
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Protein Accession
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NP_001306.1
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P38 MAPK (phospho Tyr182) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using P38 MAPK (Phospho-Tyr182).
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Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with UV for the indicated times, using P38 MAPK (Phospho-Tyr182).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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