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產(chǎn)品資料

Progesterone Receptor (phospho Ser400) Antibody

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產(chǎn)品名稱: Progesterone Receptor (phospho Ser400) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

Progesterone Receptor (phospho Ser400) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。Progesterone Receptor (phospho Ser400) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


Progesterone Receptor (phospho Ser400) Antibody  的詳細(xì)介紹

Progesterone Receptor (phospho Ser400) AntibodyProduct Profile

Product Name Progesterone Receptor (phospho Ser400) Antibody
Antibody Type Primary Antibodies
Product description
					
Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.1) Hagan CR, Knutson TP, Lange CA (2013) Nucleic Acids Res 41, 8926-42
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Immunogen
Progesterone Receptor (phospho Ser400) antibody was raised against a peptide sequence around phosphorylation site of serine 400 (A-R-S (p)-P-R) derived from Human Progesterone Receptor.

Progesterone Receptor (phospho Ser400) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

Progesterone Receptor (phospho Ser400) AntibodyTarget Information

Gene Symbol PGR
Alternative Names
NR3C3
PGR
PRGR
Progesterone receptor
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Molecular Weight(MW) 99 kDa
Tissue Specificity The antibody detects endogenous level of Progesterone Receptor only when phosphorylated at serine 400.

Progesterone Receptor (phospho Ser400) AntibodyDatabase Links

Entrez Gene 5241
Protein Accession NP_000917.3

Progesterone Receptor (phospho Ser400) AntibodyApplication

  • Application

    Western blot analysis of extracts from 293 cells treated with Heatshock using Phospho-Progesterone Receptor (Ser400) Antibody. The lane on the right is treated with the antigen-specific peptide.

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20?C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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