FKHR (phospho Ser319) Antibody
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產(chǎn)品名稱: FKHR (phospho Ser319) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
FKHR (phospho Ser319) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FKHR (phospho Ser319) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
FKHR (phospho Ser319) Antibody
的詳細介紹
FKHR (phospho Ser319) AntibodyProduct Profile
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Product Name
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FKHR (phospho Ser319) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q141) Rena G, et al. (2002) EMBO J 21 (9): 2263-2271. Woods YL, et al. (2001) Biochem J355 (Pt 3): 597-607. Rena G, et al. (2001) Biochem J 354 (Pt 3): 605-612.
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Immunogen
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FKHR (Phospho-Ser319) antibody was raised against a peptide sequence around phosphorylation site of serine 319 (T-S-S (p) -N-A) derived from Human FKHR/FOXO1A.
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FKHR (phospho Ser319) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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FKHR (phospho Ser319) AntibodyTarget Information
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Gene Symbol
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FOXO1
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Alternative Names
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FKH1
FKHR
FOXO1A
MEK2
MKK2
PRKMK2
FOXO1
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Molecular Weight(MW)
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78 - 82 kDa
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Tissue Specificity
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This antibody detects endogenous level of FKHR only when phosphorylated at serine 319.
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FKHR (phospho Ser319) AntibodyDatabase Links
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Entrez Gene
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2308
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Protein Accession
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NP_002006.2
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FKHR (phospho Ser319) AntibodyApplication
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FKHR (Phospho-Ser319). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using FKHR (Phospho-Ser319).
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Application
Western blot analysis of lysed extracts from 3T3 cells untreated or treated with serum starvation using FKHR (Phospho-Ser319).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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