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產(chǎn)品名稱: IGF1 Receptor Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IGF1 Receptor Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。IGF1 Receptor Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
IGF1 Receptor Antibody
的詳細(xì)介紹
IGF1 Receptor AntibodyProduct Profile
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Product Name
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IGF1 Receptor Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.1) Song, R.X., et al., Proc. Natl. Acad. Sci. U.S.A. 101(7):2076-2081 (2004).
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Immunogen
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This IGF1 Receptor (IGF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-51 amino acids from the N-terminal region of human IGF1 Receptor (IGF1R).
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IGF1 Receptor AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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Ig
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Host Species
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Rabbit
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Tested Applications
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IHC-PWB
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For WB starting dilution is: 1:2000 For IHC-P starting dilution is: 1:50~100:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Unpurified
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IGF1 Receptor AntibodyTarget Information
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Gene Symbol
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IGF1R
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Alternative Names
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Insulin-like growth factor 1 receptor
Insulin-like growth factor I receptor
IGF-I receptor
CD221
Insulin-like growth factor 1 receptor alpha chain
Insulin-like growth factor 1 receptor beta chain
IGF1R
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Molecular Weight(MW)
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155 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Mouse
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IGF1 Receptor AntibodyDatabase Links
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Entrez Gene
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3480
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Protein Accession
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P08069
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IGF1 Receptor AntibodyApplication
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Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma.
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Application
Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: A549 whole cell lysate Lysates/proteins at 20 ug per lane.
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Application Notes
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For WB starting dilution is: 1:2000 For IHC-P starting dilution is: 1:50~100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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Supplied in PBS with 0.09% (W/V) sodium azide.
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