IGF 1R (phospho Tyr1280) Antibody
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產(chǎn)品名稱: IGF 1R (phospho Tyr1280) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IGF 1R (phospho Tyr1280) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。IGF 1R (phospho Tyr1280) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
IGF 1R (phospho Tyr1280) Antibody
的詳細(xì)介紹
IGF 1R (phospho Tyr1280) AntibodyProduct Profile
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Product Name
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IGF 1R (phospho Tyr1280) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.1) Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1): 427-35
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Immunogen
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IGF-1R (Phospho-Tyr1280) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y (p) -Y-S) derived from Human IGF-1R.
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IGF 1R (phospho Tyr1280) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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IGF 1R (phospho Tyr1280) AntibodyTarget Information
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Gene Symbol
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IGF1R
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Alternative Names
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IGFR
CD221
IGFIR
JTK13
P53
IGFR
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Molecular Weight(MW)
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200, 95 kDa
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Tissue Specificity
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This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.
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IGF 1R (phospho Tyr1280) AntibodyDatabase Links
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Entrez Gene
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3480
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Protein Accession
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NP_000866.1
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IGF 1R (phospho Tyr1280) AntibodyApplication
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Application
Western blot analysis of extract from 293 cells using IGF-1R (Phospho-Tyr1280).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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