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產(chǎn)品名稱(chēng): SNCA Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
SNCA Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。SNCA Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
SNCA Antibody
的詳細(xì)介紹
SNCA AntibodyProduct Profile
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Product Name
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SNCA Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Alpha-Synuclein (SNCA) is a hallmark of Alzheimer’s disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson’s disease (4,5).1) Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.
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Immunogen
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SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA. The immunogen is located within the last 50 amino acids of SNCA.
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SNCA AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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ELISAIFIHC-PWB
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SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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SNCA AntibodyTarget Information
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Gene Symbol
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SNCA
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Alternative Names
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SNCA Antibody: PD1
NACP
PARK1
PARK4
Alpha-synuclein
Non-A beta component of AD amyloid
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Molecular Weight(MW)
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Predicted: 12 kDa Observed: 16 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)
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Tissue Specificity
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SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.
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SNCA AntibodyDatabase Links
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Entrez Gene
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6622
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Protein Accession
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NP_000336
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SNCA AntibodyApplication
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Application
Western blot analysis of 1 ng of recombinant human SNCA with SNCA antibody at 1 μg/ml.
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Application
Immunohistochemistry of SNCA in rat brain tissue with SNCA antibody at 5 μg/ml.
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Application
Immunofluorescence of SNCA in rat brain tissue with SNCA antibody at 20 μg/ml.
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Application
Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 μg/ml.
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Positive Control
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1) Cat. No. 1412 - Mouse Cerebellum Tissue Lysate
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Application Notes
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SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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SNCA antibody can be stored at 4?C for three months and -20?C, stable for up to one year.
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Storage Buffer
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SNCA antibody is supplied in PBS containing 0.02% sodium azide.
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