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產(chǎn)品資料

SNCA Antibody

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產(chǎn)品名稱(chēng): SNCA Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔

簡(jiǎn)單介紹

SNCA Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。SNCA Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


SNCA Antibody  的詳細(xì)介紹

SNCA AntibodyProduct Profile

Product Name SNCA Antibody
Antibody Type Primary Antibodies
Product description
					
Alpha-Synuclein (SNCA) is a hallmark of Alzheimer’s disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson’s disease (4,5).1) Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.
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Immunogen
SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA. The immunogen is located within the last 50 amino acids of SNCA.

SNCA AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAIFIHC-PWB

SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

SNCA AntibodyTarget Information

Gene Symbol SNCA
Alternative Names
SNCA Antibody: PD1
NACP
PARK1
PARK4
Alpha-synuclein
Non-A beta component of AD amyloid
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Molecular Weight(MW) Predicted: 12 kDa Observed: 16 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)
Tissue Specificity SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

SNCA AntibodyDatabase Links

Entrez Gene 6622
Protein Accession NP_000336

SNCA AntibodyApplication

  • Application

    Western blot analysis of 1 ng of recombinant human SNCA with SNCA antibody at 1 μg/ml.

  • Application

    Immunohistochemistry of SNCA in rat brain tissue with SNCA antibody at 5 μg/ml.

  • Application

    Immunofluorescence of SNCA in rat brain tissue with SNCA antibody at 20 μg/ml.

  • Application

    Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 μg/ml.

Positive Control 1) Cat. No. 1412 - Mouse Cerebellum Tissue Lysate
Application Notes
SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:

Additional Information

Form Liquid
Storage Instructions SNCA antibody can be stored at 4?C for three months and -20?C, stable for up to one year.
Storage Buffer SNCA antibody is supplied in PBS containing 0.02% sodium azide.

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