a Synuclein (phospho Tyr125) Antibody
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產(chǎn)品名稱: a Synuclein (phospho Tyr125) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
a Synuclein (phospho Tyr125) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。a Synuclein (phospho Tyr125) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
a Synuclein (phospho Tyr125) Antibody
的詳細(xì)介紹
a Synuclein (phospho Tyr125) AntibodyProduct Profile
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Product Name
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a Synuclein (phospho Tyr125) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons1) Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
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Immunogen
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a-Synuclein (Phospho-Tyr125) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y (p) -E-M) derived from Human α-Synuclein.
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a Synuclein (phospho Tyr125) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFWB
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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a Synuclein (phospho Tyr125) AntibodyTarget Information
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Gene Symbol
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SNCA
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Alternative Names
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PD1
NACP
PARK1
PARK4
CD135
FLK2
STK1
SYN
SYUA
alpha-synuclein
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Molecular Weight(MW)
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18 kDa
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Tissue Specificity
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This antibody detects endogenous level of α-Synuclein only when phosphorylated at tyrosine 125.
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a Synuclein (phospho Tyr125) AntibodyDatabase Links
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Entrez Gene
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6622
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Protein Accession
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NP_000336.1
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a Synuclein (phospho Tyr125) AntibodyApplication
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Application
Immunofluorescence staining of methanol-fixed HeLa cells using α-Synuclein (Phospho-Tyr125).
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Application
Western blot analysis of lysed extracts from C2C12 cells untreated or treated with Anisomycin using α-Synuclein (Phospho-Tyr125).
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Application Notes
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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