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產(chǎn)品資料

Alpha synuclein (phospho Ser129) Antibody

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產(chǎn)品名稱: Alpha synuclein (phospho Ser129) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

Alpha synuclein (phospho Ser129) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Alpha synuclein (phospho Ser129) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


Alpha synuclein (phospho Ser129) Antibody  的詳細(xì)介紹

Alpha synuclein (phospho Ser129) AntibodyProduct Profile

Product Name Alpha synuclein (phospho Ser129) Antibody
Antibody Type Primary Antibodies
Product description
					
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).1) Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem Jan 7;275(1): 390-7.
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Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein.

Alpha synuclein (phospho Ser129) AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Species Reactivity

BovineDogMouseRat

Concentration 1mg/ml
Purification Affinity purified

Alpha synuclein (phospho Ser129) AntibodyTarget Information

Gene Symbol Snca
Alternative Names
Alpha-synuclein
Molecular Weight(MW) 15

Alpha synuclein (phospho Ser129) AntibodyDatabase Links

Entrez Gene 29219
Protein Accession P37377

Alpha synuclein (phospho Ser129) AntibodyApplication

  • Application

    Western blot of rat cortex lysate showing specific labeling of the ~15 k alpha synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown).

Application Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human, mouse, and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information

Form Liquid
Storage Instructions Alpha synuclein antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

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