Alpha synuclein (phospho Ser129) Antibody
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產(chǎn)品名稱: Alpha synuclein (phospho Ser129) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Alpha synuclein (phospho Ser129) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Alpha synuclein (phospho Ser129) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
Alpha synuclein (phospho Ser129) Antibody
的詳細介紹
Alpha synuclein (phospho Ser129) AntibodyProduct Profile
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Product Name
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Alpha synuclein (phospho Ser129) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).1) Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem Jan 7;275(1): 390-7.
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Immunogen
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Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein.
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Alpha synuclein (phospho Ser129) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Species Reactivity
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BovineDogMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Alpha synuclein (phospho Ser129) AntibodyTarget Information
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Gene Symbol
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Snca
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Alternative Names
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Alpha-synuclein
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Molecular Weight(MW)
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15
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Alpha synuclein (phospho Ser129) AntibodyDatabase Links
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Entrez Gene
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29219
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Protein Accession
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P37377
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Alpha synuclein (phospho Ser129) AntibodyApplication
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Application
Western blot of rat cortex lysate showing specific labeling of the ~15 k alpha synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown).
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Application Notes
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The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human, mouse, and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Alpha synuclein antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
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Storage Buffer
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100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
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