CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.1) Mao S., Frank R. C., Zhang J., Miyazaki Y., Nimer S. D. Mol. Cell. Biol. 19:3635-3644 (1999) Pelletier N., Champagne N., Stifani S., Yang X. -J. Oncogene 21:2729-2740 (2002) Cho J. -Y., Akbarali Y., Zerbini L. F., Gu X., Boltax J., Wang Y., Oettgen P., Zhang D. -E., Libermann T. A. J. Biol. Chem. 279:19512-19522 (2004)
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