AML1 (phospho Ser435) Antibody
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產(chǎn)品名稱: AML1 (phospho Ser435) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
AML1 (phospho Ser435) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。AML1 (phospho Ser435) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
AML1 (phospho Ser435) Antibody
的詳細(xì)介紹
AML1 (phospho Ser435) AntibodyProduct Profile
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Product Name
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AML1 (phospho Ser435) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.1) Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).
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Immunogen
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AML1 (phospho Ser435) antibody was raised against a peptide sequence around phosphorylation site of Serine 435 ( S-N-S (p)-P-T) derived from Human AML1.
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AML1 (phospho Ser435) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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AML1 (phospho Ser435) AntibodyTarget Information
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Gene Symbol
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RUNX1
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Alternative Names
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Acute myeloid leukemia 1 protein
CBFA2
CBFA2
alpha 2 subunit
RUNX1
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Molecular Weight(MW)
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53 kDa
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Tissue Specificity
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The antibody detects endogenous levels of AML1 only when phosphorylated at serine 435.
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AML1 (phospho Ser435) AntibodyDatabase Links
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Entrez Gene
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861
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Protein Accession
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NP_001001890.1
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AML1 (phospho Ser435) AntibodyApplication
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Application
Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using AML1 (Phospho-Ser435) Antibody. The lane on the left is treated with antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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