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產(chǎn)品資料

FGFR1 (phospho Tyr766) Antibody

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產(chǎn)品名稱: FGFR1 (phospho Tyr766) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

FGFR1 (phospho Tyr766) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FGFR1 (phospho Tyr766) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


FGFR1 (phospho Tyr766) Antibody  的詳細(xì)介紹

FGFR1 (phospho Tyr766) AntibodyProduct Profile

Product Name FGFR1 (phospho Tyr766) Antibody
Antibody Type Primary Antibodies
Product description
					
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.1) Cross MJ, et al. (2002) Mol Biol Cell 13, 2881-93. Foehr ED, Raffioni S, Murray-Rust J, Bradshaw RA (2001)J Biol Chem 276, 37529-36. Cross MJ, et al. (2000)J Cell Sci 113 ( Pt 4), 643-51 .
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Immunogen
FGFR1 (phospho Tyr766) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y (p)-L-D) derived from FGFR1.

FGFR1 (phospho Tyr766) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

FGFR1 (phospho Tyr766) AntibodyTarget Information

Gene Symbol FGFR1
Alternative Names
FGFBR
FGFR-1
FLG
FLT2
c-fgr
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Molecular Weight(MW) 140 kDa
Tissue Specificity The antibody detects endogenous level of FGFR1 only when phosphorylated at tyrosine 766.

FGFR1 (phospho Tyr766) AntibodyDatabase Links

Entrez Gene 2260
Protein Accession NP_001167534.1

FGFR1 (phospho Tyr766) AntibodyApplication

  • FGFR1 (phospho Tyr766) Antibody
    Application

    Western blot analysis of extracts from HepG2 cells treated with EGF using Phospho-FGFR1 (Tyr766) Antibody. The lane on the right is treated with the antigen-specific peptide.

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20?C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

滬公網(wǎng)安備 31011702004356號

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