PAK1 (phospho Ser199) Antibody
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產(chǎn)品名稱: PAK1 (phospho Ser199) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
PAK1 (phospho Ser199) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。PAK1 (phospho Ser199) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
PAK1 (phospho Ser199) Antibody
的詳細介紹
PAK1 (phospho Ser199) AntibodyProduct Profile
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Product Name
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PAK1 (phospho Ser199) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.1) Brown J.L., Curr. Biol. 6:598-605(1996).
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Immunogen
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PAK1 (phospho Ser199) antibody was raised against a peptide sequence around phosphorylation site of Serine 199 (T-K-S (p)-V-I) derived from Human PAK1.
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PAK1 (phospho Ser199) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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PAK1 (phospho Ser199) AntibodyTarget Information
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Gene Symbol
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PAK1
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Alternative Names
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ADRB2
PAK 1
P65-PAK
P68-PAK
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Molecular Weight(MW)
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61 kDa
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Tissue Specificity
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The antibody detects endogenous levels of PAK1/2 only when phosphorylated at serine 199.
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PAK1 (phospho Ser199) AntibodyDatabase Links
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Entrez Gene
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5058
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Protein Accession
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NP_002567.3
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PAK1 (phospho Ser199) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human placenta tissue using PAK1/2 (Phospho-Ser199) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Application
Western blot analysis of extracts from LOVO cells treated with starved using PAK1/2 (Phospho-Ser199) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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