PAK1 (phospho Thr212) Antibody
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產(chǎn)品名稱: PAK1 (phospho Thr212) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
PAK1 (phospho Thr212) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。PAK1 (phospho Thr212) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
PAK1 (phospho Thr212) Antibody
的詳細(xì)介紹
PAK1 (phospho Thr212) AntibodyProduct Profile
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Product Name
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PAK1 (phospho Thr212) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.1) Alexander K, et al. (2004) Mol Cell Biol; 24: 2808-2819Thiel DA, et al. (2002) Curr Biol; 12:1227-1232Rashid T, et al. (2001) J. Biol. Chem; 276: 49043 - 49052.
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Immunogen
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PAK1 (Phospho-Thr212) antibody was raised against a peptide sequence around phosphorylation site of threonine 212 (P-V-T (p) -P-T) derived from Human PAK1.
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PAK1 (phospho Thr212) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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PAK1 (phospho Thr212) AntibodyTarget Information
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Gene Symbol
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PAK1
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Alternative Names
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PAKalpha
C1orf215
LAP18
OP18
p21-activated kinase 1
PAK-1
p65-PAK
Alpha-PAK
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Molecular Weight(MW)
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68 kDa
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Tissue Specificity
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This antibody detects endogenous level of PAK1 only when phosphorylated at threonine 212.
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PAK1 (phospho Thr212) AntibodyDatabase Links
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Entrez Gene
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5058
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Protein Accession
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NP_001122092.1
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PAK1 (phospho Thr212) AntibodyApplication
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1 (Phospho-Thr212). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using PAK1 (Phospho-Thr212).
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Application
Western blot analysis of lysed extracts from 293 cells untreated or treated with forskolin using PAK1 (Phospho-Thr212).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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