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產(chǎn)品名稱: MEK1/2 Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
MEK1/2 Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。MEK1/2 Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
MEK1/2 Antibody
的詳細(xì)介紹
MEK1/2 AntibodyProduct Profile
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Product Name
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MEK1/2 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) and the highly homologous MEK2 are members of the dual specificity protein kinase family (1). MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals (2). MEK1 lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (2).1) Zheng CF and Guan KL. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 1993; 268:11435-9.
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Immunogen
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MEK1/2 antibody was raised against a 15 amino acid peptide near the center of human MEK1. The immunogen is located within amino acids 240 - 290 of MEK1/2.
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MEK1/2 AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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ELISAIFIHC-PWB
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MEK1/2 antibody can be used for detection of MEK1/2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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MEK1/2 AntibodyTarget Information
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Gene Symbol
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MAP2K1
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Alternative Names
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Mitogen-activated protein kinase kinase 1
MAP2K1
MAPKK1
MEK1
MKK1
PRKMK1
CFC3
Mitogen-activated protein kinase kinase 2
MAP2K2
MAPKK2
MEK2
MKK2
PRKMK2
CFC
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Molecular Weight(MW)
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Predicted: 43 kDa Observed: 44 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Rabbit: (100%)
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Tissue Specificity
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MEK1/2 antibody is human, mouse, and rat reactive. This antibody detects both MEK1 and MEK2.
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MEK1/2 AntibodyDatabase Links
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Entrez Gene
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5604
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Protein Accession
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NP_002746
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MEK1/2 AntibodyApplication
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Application
Immunofluorescence of MEK1/2 in mouse brain tissue with MEK1/2 antibody at 20 μg/mL.
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Application
Immunohistochemistry of MEK1/2 in mouse brain tissue with MEK1/2 antibody at 5 μg/mL.
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Positive Control
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1) Cat. No. 1303 - Human Brain Tissue Lysate
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Application Notes
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MEK1/2 antibody can be used for detection of MEK1/2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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MEK1/2 antibody can be stored at 4?C for three months and -20?C, stable for up to one year.
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Storage Buffer
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MEK1/2 antibody is supplied in PBS containing 0.02% sodium azide.
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