IkB a (phospho Tyr42) Antibody
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產(chǎn)品名稱: IkB a (phospho Tyr42) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IkB a (phospho Tyr42) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。IkB a (phospho Tyr42) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
IkB a (phospho Tyr42) Antibody
的詳細介紹
IkB a (phospho Tyr42) AntibodyProduct Profile
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Product Name
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IkB a (phospho Tyr42) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.1) Beraud C, et al. (1999) Proc Natl Acad Sci U S A 96 (2): 429-434. Sundstrom S, et al. (2005) J Virol 79 (4): 2230-2239. Liu L, et al. (1998) Mol Cell Biol 18 (7): 4221-4234. Shrivastava A, et al. (1998) J Virol 72 (12): 9722-9728.
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Immunogen
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IkB-a (Phospho-Tyr42) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y (p) -E-Q) derived from Human IkappaB-α.
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IkB a (phospho Tyr42) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHC
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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MouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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IkB a (phospho Tyr42) AntibodyTarget Information
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Gene Symbol
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NFKBIA
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Alternative Names
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IKBA
MAD-3
NFKBI
CDC2
CDC28A
CDKN1
P34CDC2
IKBA
NFKBIA
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Molecular Weight(MW)
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39 kDa
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Tissue Specificity
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This antibody detects endogenous levels of IkappaB-α only when phosphorylated at tyrosine 42.
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IkB a (phospho Tyr42) AntibodyDatabase Links
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Entrez Gene
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4792
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Protein Accession
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NP_065390.1
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IkB a (phospho Tyr42) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-α (phospho-Tyr42).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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