syk (phospho Tyr323) Antibody
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產(chǎn)品名稱: syk (phospho Tyr323) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
syk (phospho Tyr323) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。syk (phospho Tyr323) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
syk (phospho Tyr323) Antibody
的詳細介紹
syk (phospho Tyr323) AntibodyProduct Profile
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Product Name
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syk (phospho Tyr323) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C γdependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion1) Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447. Turner, M. et al. (2000) Immunol. Today 21, 148-154. Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874. Law, C. L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315.
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Immunogen
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syk (phospho-Tyr323) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 323 (N-P-Y (p) -E- P) derived from Human syk.
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syk (phospho Tyr323) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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syk (phospho Tyr323) AntibodyTarget Information
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Gene Symbol
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SYK
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Alternative Names
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p72-Syk
HSP27
HSP28
Spleen tyrosine kinase
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Molecular Weight(MW)
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72 kDa
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Tissue Specificity
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This antibody detects endogenous level of syk only when phosphorylated at tyrosine 323.
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syk (phospho Tyr323) AntibodyDatabase Links
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Entrez Gene
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6850
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Protein Accession
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NP_001128524.1
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syk (phospho Tyr323) AntibodyApplication
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Application
Western blot analysis of lysed extracts from JK cells untreated or treated with H2O2 for the indicated times, using syk (phospho-Tyr323).
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using syk (Phospho-Tyr323). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using syk (phospho-Tyr323).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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