p90 RSK (phospho Thr573) Antibody
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產(chǎn)品名稱: p90 RSK (phospho Thr573) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p90 RSK (phospho Thr573) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p90 RSK (phospho Thr573) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
p90 RSK (phospho Thr573) Antibody
的詳細(xì)介紹
p90 RSK (phospho Thr573) AntibodyProduct Profile
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Product Name
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p90 RSK (phospho Thr573) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.1) Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.
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Immunogen
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p90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p)-P-C) derived from Human p90 RSK.
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p90 RSK (phospho Thr573) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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p90 RSK (phospho Thr573) AntibodyTarget Information
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Gene Symbol
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RPS6KA1
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Alternative Names
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KS6A1
p90RSK1
RSK1
RPS6KA1
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Molecular Weight(MW)
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95 kDa
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Tissue Specificity
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The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.
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p90 RSK (phospho Thr573) AntibodyDatabase Links
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Entrez Gene
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6195
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Protein Accession
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NP_002944.2
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p90 RSK (phospho Thr573) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Application
Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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