Cyclin D1 (phospho Thr286) Antibody
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產(chǎn)品名稱: Cyclin D1 (phospho Thr286) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Cyclin D1 (phospho Thr286) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Cyclin D1 (phospho Thr286) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
Cyclin D1 (phospho Thr286) Antibody
的詳細介紹
Cyclin D1 (phospho Thr286) AntibodyProduct Profile
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Product Name
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Cyclin D1 (phospho Thr286) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.1) Liou YC, et al. (2002) Proc Natl Acad Sci U S A 99, 1335-40
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Immunogen
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Cyclin D1 (phospho Thr286) antibody was raised against a peptide sequence around phosphorylation site of threonine 286 (A-C-T (p)-P-T) derived from Human Cyclin D1.
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Cyclin D1 (phospho Thr286) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Species Reactivity
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MouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Cyclin D1 (phospho Thr286) AntibodyTarget Information
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Gene Symbol
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CCND1
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Alternative Names
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BCL-1
oncogene
CYL-1
PRAD1
PRAD1
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Molecular Weight(MW)
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33 kDa
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Tissue Specificity
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The antibody detects endogenous level of Cyclin D1 only when phosphorylated at threonine 286.
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Cyclin D1 (phospho Thr286) AntibodyDatabase Links
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Entrez Gene
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595
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Protein Accession
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NP_444284.1
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Cyclin D1 (phospho Thr286) AntibodyApplication
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Application
Western blot analysis of extracts from MCF7 tissue using Cyclin D1 (Phospho-Thr286) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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