Pyk2 (phospho Tyr402) Antibody
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產(chǎn)品名稱: Pyk2 (phospho Tyr402) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Pyk2 (phospho Tyr402) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Pyk2 (phospho Tyr402) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
Pyk2 (phospho Tyr402) Antibody
的詳細介紹
Pyk2 (phospho Tyr402) AntibodyProduct Profile
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Product Name
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Pyk2 (phospho Tyr402) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.1) Gluck SL, et al. (2004) J Clin Invest; 114 (12): 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98 (17): 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22 (8): 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21 (12): 4016-4031Krishnan HH, et al. (2006) J Virol; 80 (3): 1167-1180
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Immunogen
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Pyk2 (Phospho-Tyr402) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y (p) -A-E) derived from Human Pyk2.
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Pyk2 (phospho Tyr402) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Pyk2 (phospho Tyr402) AntibodyTarget Information
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Gene Symbol
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PTK2B
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Alternative Names
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PKB
PTK
CAKB
FAK2
PYK2
CADTK
FADK2
RAFTK
MAPTL
MTBT1
TAU
FADK 2
Focal adhesion kinase 2
PTK2B
Proline-rich tyrosine kinase 2 RAFTK
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Molecular Weight(MW)
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116 kDa
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Tissue Specificity
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This antibody detects endogenous level of Pyk2 only when phosphorylated at tyrosine 402.
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Pyk2 (phospho Tyr402) AntibodyDatabase Links
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Entrez Gene
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2185
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Protein Accession
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NP_004094.3
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Pyk2 (phospho Tyr402) AntibodyApplication
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Application
Western blot analysis of lysed extracts from 293 cells untreated or treated with Serum using Pyk2 (Phospho-Tyr402).
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2 (Phospho-Tyr402). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using Pyk2 (Phospho-Tyr402).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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