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產(chǎn)品名稱: STAT5b Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
STAT5b Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。STAT5b Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
STAT5b Antibody
的詳細(xì)介紹
STAT5b AntibodyProduct Profile
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Product Name
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STAT5b Antibody
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Antibody Type
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Primary Antibodies
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Product description
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STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, ***** mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.1) Xi, S., et al., Cancer Res. 63(20):6763-6771 (2003).
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Immunogen
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This STAT5b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
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STAT5b AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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Ig
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Host Species
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Rabbit
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Tested Applications
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IHC-PWB
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For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Unpurified
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STAT5b AntibodyTarget Information
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Gene Symbol
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STAT5B
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Alternative Names
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Signal transducer and activator of transcription 5B
STAT5B
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Molecular Weight(MW)
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90 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Bovine
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STAT5b AntibodyDatabase Links
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Entrez Gene
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6777
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Protein Accession
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P51692
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STAT5b AntibodyApplication
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Application
Western blot analysis in HL-60,MCF-7,mouse NIH/3T3 cell line, rat liver and spleen lysates (35ug/lane).
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Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma.
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Application Notes
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For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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Supplied in PBS with 0.09% (W/V) sodium azide.
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