ABL1 (phospho Thr735) Antibody
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產(chǎn)品名稱: ABL1 (phospho Thr735) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
ABL1 (phospho Thr735) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。ABL1 (phospho Thr735) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
ABL1 (phospho Thr735) Antibody
的詳細(xì)介紹
ABL1 (phospho Thr735) AntibodyProduct Profile
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Product Name
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ABL1 (phospho Thr735) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.1) Fainstein E., Oncogene 4:1477-1481(1989).
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Immunogen
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ABL1 (phospho Thr735) antibody was raised against a peptide sequence around phosphorylation site of threonine735 (S-V-T (p)-L-P) derived from Human ABL1.
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ABL1 (phospho Thr735) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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ABL1 (phospho Thr735) AntibodyTarget Information
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Gene Symbol
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ABL1
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Alternative Names
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Abelson murine leukemia viral oncogene 1
ABL1
c-ABL
JTK7
p150
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Molecular Weight(MW)
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135 kDa
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Tissue Specificity
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The antibody detects endogenous levels of ABL1 only when phosphorylated at threonine 735.
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ABL1 (phospho Thr735) AntibodyDatabase Links
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Entrez Gene
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25
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Protein Accession
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NP_005148.2
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ABL1 (phospho Thr735) AntibodyApplication
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Application
Western blot analysis of extracts from COS cells treated with EGF using ABL1 (Phospho-Thr735) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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