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NMDAR1 (phospho Ser890) Antibody

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產(chǎn)品名稱: NMDAR1 (phospho Ser890) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡(jiǎn)單介紹

NMDAR1 (phospho Ser890) Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。NMDAR1 (phospho Ser890) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


NMDAR1 (phospho Ser890) Antibody  的詳細(xì)介紹

NMDAR1 (phospho Ser890) AntibodyProduct Profile

Product Name NMDAR1 (phospho Ser890) Antibody
Antibody Type Primary Antibodies
Product description
					
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.1) Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086.
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Immunogen
NMDAR1 (phospho Ser890) antibody was raised against a peptide sequence around phosphorylation site of Serine 890 (A-S-S (p)-F-K) derived from Human NMDAR1.

NMDAR1 (phospho Ser890) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IFIHC

Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

NMDAR1 (phospho Ser890) AntibodyTarget Information

Gene Symbol GRIN1
Alternative Names
GLURZ1
GRIN1
NMD-R1
NMDZ1
NMZ1
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Molecular Weight(MW) 120 kDa
Tissue Specificity The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.

NMDAR1 (phospho Ser890) AntibodyDatabase Links

Entrez Gene 2902
Protein Accession NP_015566.1

NMDAR1 (phospho Ser890) AntibodyApplication

  • Application

    Immunofluorescence staining of methanol-fixed A549 cells using NMDAR1 (Phospho-Ser890) Antibody.

  • Application

    Immunohistochemical analysis of paraffin-embedded human brain tissue using NMDAR1 (Phospho-Ser890) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
Storage Instructions Store antibody at -20?C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

滬公網(wǎng)安備 31011702004356號(hào)

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