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產(chǎn)品名稱: NMDAR1 Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
NMDAR1 Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。NMDAR1 Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
NMDAR1 Antibody
的詳細(xì)介紹
NMDAR1 AntibodyProduct Profile
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Product Name
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NMDAR1 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.1) Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1; 554 (Pt 3): 765-777
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Immunogen
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NMDAR1 (Ab-896) antibody was raised against a peptide sequence around aa.894~898 (R-R-S-S-K) derived from Human NMDAR1.
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NMDAR1 AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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NMDAR1 AntibodyTarget Information
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Gene Symbol
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GRIN1
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Alternative Names
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NR1
MRD8
GluN1
NMDA1
NMDAR1
ABL
JTK7
GLURZ1
GRIN1
NMD-R1
NMDZ1
NMZ1
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Molecular Weight(MW)
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120 kDa
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Tissue Specificity
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This antibody detects endogenous level of total NMDAR1protein.
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NMDAR1 AntibodyDatabase Links
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Entrez Gene
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2902
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Protein Accession
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NP_000823.4
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NMDAR1 AntibodyApplication
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Application
Western blot analysis of lysed extracts from PC12 and C6 cells using NMDAR1 (Ab-896).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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