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NMDAR1 (phospho Ser896) Antibody

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產(chǎn)品名稱: NMDAR1 (phospho Ser896) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡(jiǎn)單介紹

NMDAR1 (phospho Ser896) Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。NMDAR1 (phospho Ser896) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


NMDAR1 (phospho Ser896) Antibody  的詳細(xì)介紹

NMDAR1 (phospho Ser896) AntibodyProduct Profile

Product Name NMDAR1 (phospho Ser896) Antibody
Antibody Type Primary Antibodies
Product description
					
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.1) Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1; 554 (Pt 3): 765-777
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Immunogen
NMDAR1 (Phospho-Ser896) antibody was raised against a peptide sequence around phosphorylation site of serine 896 (R-R-S (p) -S-K) derived from Human NMDAR1.

NMDAR1 (phospho Ser896) AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

NMDAR1 (phospho Ser896) AntibodyTarget Information

Gene Symbol GRIN1
Alternative Names
NR1
MRD8
GluN1
NMDA1
NMDAR1
BBC6
BCL2L8
GLURZ1
GRIN1
NMD-R1
NMDZ1
NMZ1
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Molecular Weight(MW) 120 kDa
Tissue Specificity This antibody detects endogenous level of NMDAR1 only when phosphorylated at serine896.

NMDAR1 (phospho Ser896) AntibodyDatabase Links

Entrez Gene 2902
Protein Accession NP_000823.4

NMDAR1 (phospho Ser896) AntibodyApplication

  • Application

    Western blot analysis of lysed extracts from Mouse Brain tissue using NMDAR1 (Phospho-Ser896).

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20?C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

滬公網(wǎng)安備 31011702004356號(hào)

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