TrkA (phospho Ser791) Antibody
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產(chǎn)品名稱: TrkA (phospho Ser791) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
TrkA (phospho Ser791) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。TrkA (phospho Ser791) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
TrkA (phospho Ser791) Antibody
的詳細介紹
TrkA (phospho Ser791) AntibodyProduct Profile
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Product Name
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TrkA (phospho Ser791) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.1) Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43): 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30): 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33): 24175-84
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Immunogen
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TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA.
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TrkA (phospho Ser791) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFWB
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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TrkA (phospho Ser791) AntibodyTarget Information
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Gene Symbol
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NTRK1
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Alternative Names
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MTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
MGF
SCF
High affinity nerve growth factor receptor precursor
NTRK1
Slow nerve growth factor receptor
TRK1 transforming tyrosine kinase protein
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Molecular Weight(MW)
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140 kDa
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Tissue Specificity
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This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.
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TrkA (phospho Ser791) AntibodyDatabase Links
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Entrez Gene
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4914
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Protein Accession
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NP_001007793.1
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TrkA (phospho Ser791) AntibodyApplication
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Application
Western blot analysis of lysed extracts from Rat and Mouse brain tissue using TrkA (Phospho-Ser791).
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Application
Immunofluorescence staining of methanol-fixed HeLa cells using TrkA (Phospho-Ser791).
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Application Notes
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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