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產(chǎn)品資料

Trk A (phospho Tyr757) Antibody

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產(chǎn)品名稱: Trk A (phospho Tyr757) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

Trk A (phospho Tyr757) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Trk A (phospho Tyr757) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用:WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。


Trk A (phospho Tyr757) Antibody  的詳細(xì)介紹


Trk A (phospho Tyr757) AntibodyProduct Profile

Product Name Trk A (phospho Tyr757) Antibody
Antibody Type Primary Antibodies
Product description
				
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.1) Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).
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Immunogen
Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p)-A-I) derived from Human Trk A.

Trk A (phospho Tyr757) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHC

Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification Affinity purified

Trk A (phospho Tyr757) AntibodyTarget Information

Gene Symbol NTRK1
Alternative Names
TRKA
TRK
NTRK1
p140-TrkA
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Molecular Weight(MW) 87 kDa
Tissue Specificity The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.

Trk A (phospho Tyr757) AntibodyDatabase Links

Entrez Gene 4914
Protein Accession NP_002520.2

Trk A (phospho Tyr757) AntibodyApplication

  • Trk A (phospho Tyr757) Antibody
    Application

    Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
Storage Instructions Store antibody at -20?C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


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