Trk A (phospho Tyr757) Antibody
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產(chǎn)品名稱: Trk A (phospho Tyr757) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Trk A (phospho Tyr757) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Trk A (phospho Tyr757) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Trk A (phospho Tyr757) Antibody
的詳細(xì)介紹
Trk A (phospho Tyr757) AntibodyProduct Profile
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Product Name
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Trk A (phospho Tyr757) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.1) Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).
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Immunogen
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Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p)-A-I) derived from Human Trk A.
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Trk A (phospho Tyr757) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHC
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Trk A (phospho Tyr757) AntibodyTarget Information
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Gene Symbol
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NTRK1
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Alternative Names
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TRKA
TRK
NTRK1
p140-TrkA
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Molecular Weight(MW)
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87 kDa
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Tissue Specificity
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The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.
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Trk A (phospho Tyr757) AntibodyDatabase Links
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Entrez Gene
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4914
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Protein Accession
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NP_002520.2
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Trk A (phospho Tyr757) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody (left) or the same antibody preincubated with blocking peptide (right).
Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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