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產(chǎn)品名稱: Connexin Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Connexin Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Connexin Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Connexin Antibody
的詳細(xì)介紹
Connexin AntibodyProduct Profile
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Product Name
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Connexin Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).1) Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berl) 101:449-459.
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Immunogen
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Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
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Connexin AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity
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ChickenDogHumanMouseRatSheepXenopusZebra Fish
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Connexin AntibodyTarget Information
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Gene Symbol
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Gja1
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Alternative Names
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Cx43
Cxn-43
Connexin-43
Cx43
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Molecular Weight(MW)
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43
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Connexin AntibodyDatabase Links
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Entrez Gene
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24392
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Protein Accession
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P08050
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Connexin AntibodyApplication
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Application
Western blot of rat cerebellar lysate showing specific immunolabeling of the ~43k connexin43 protein.
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Application Notes
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The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Connexin antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
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Storage Buffer
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100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
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