如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: Connexin Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Connexin Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Connexin Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Connexin Antibody
的詳細(xì)介紹
Connexin AntibodyProduct Profile
|
Product Name
|
Connexin Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).1) Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berl) 101:449-459.
More
|
|
Immunogen
|
Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
|
Connexin AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
WB
|
|
|
The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
More
|
|
Species Reactivity
|
ChickenDogHumanMouseRatSheepXenopusZebra Fish
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
Connexin AntibodyTarget Information
|
Gene Symbol
|
Gja1
|
|
Alternative Names
|
Cx43
Cxn-43
Connexin-43
Cx43
More
|
|
Molecular Weight(MW)
|
43
|
Connexin AntibodyDatabase Links
|
Entrez Gene
|
24392
|
|
Protein Accession
|
P08050
|
Connexin AntibodyApplication
-
Application
Western blot of rat cerebellar lysate showing specific immunolabeling of the ~43k connexin43 protein.
|
Application Notes
|
The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
More
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Connexin antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
|
|
Storage Buffer
|
100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
|
