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產品資料

PARP-1 Antibody

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產品名稱: PARP-1 Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔

簡單介紹

PARP-1 Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。PARP-1 Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。


PARP-1 Antibody  的詳細介紹

PARP-1 AntibodyProduct Profile

Product Name PARP-1 Antibody
Antibody Type Primary Antibodies
Product description 
					

						PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
					

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Immunogen 
Recombinant mouse PARP-1 [ARTD1] (aa 215-525).

PARP-1 AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

ICCIHCIPWB

Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:
Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification

PARP-1 AntibodyTarget Information

Gene Symbol Parp1
Alternative Names
Poly(ADP-ribose) Polymerase 1
ADP-ribosyltransferase Diphtheria Toxin-like 1
NAD(+) ADP-ribosyltransferase 1
Tissue Specificity Recognizes mouse PARP-1. Cross-reacts weakly with human PARP-1.

PARP-1 AntibodyDatabase Links

Entrez Gene 11545
Protein Accession P11103

PARP-1 AntibodyApplication

Application Notes
Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:

Additional Information

Form Liquid
Storage Instructions Stable for at least 1 year after receipt when stored at -20?C.
Storage Buffer Liquid. Contains 0.1% sodium azide.

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