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產(chǎn)品名稱: PARP-1 Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
PARP-1 Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。PARP-1 Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
PARP-1 Antibody
的詳細(xì)介紹
PARP-1 AntibodyProduct Profile
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Product Name
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PARP-1 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
More
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Immunogen
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Recombinant mouse PARP-1 [ARTD1] (aa 215-525).
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PARP-1 AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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ICCIHCIPWB
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Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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PARP-1 AntibodyTarget Information
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Gene Symbol
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Parp1
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Alternative Names
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Poly(ADP-ribose) Polymerase 1
ADP-ribosyltransferase Diphtheria Toxin-like 1
NAD(+) ADP-ribosyltransferase 1
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Tissue Specificity
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Recognizes mouse PARP-1. Cross-reacts weakly with human PARP-1.
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PARP-1 AntibodyDatabase Links
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Entrez Gene
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11545
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Protein Accession
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P11103
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PARP-1 AntibodyApplication
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Application Notes
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Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Stable for at least 1 year after receipt when stored at -20?C.
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Storage Buffer
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Liquid. Contains 0.1% sodium azide.
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